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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SAMHD1
All Species:
17.58
Human Site:
Y553
Identified Species:
32.22
UniProt:
Q9Y3Z3
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y3Z3
NP_056289.2
626
72201
Y553
A
E
Q
L
I
R
V
Y
C
K
K
V
D
R
K
Chimpanzee
Pan troglodytes
XP_514624
382
43769
K312
R
N
G
I
D
V
D
K
W
D
Y
F
A
R
D
Rhesus Macaque
Macaca mulatta
XP_001097562
728
83194
Y655
A
E
Q
L
I
R
V
Y
C
K
K
M
D
R
K
Dog
Lupus familis
XP_542986
665
76981
Y592
A
E
Q
L
I
R
V
Y
C
K
K
T
D
A
D
Cat
Felis silvestris
Mouse
Mus musculus
Q60710
627
72632
K555
V
S
Q
L
L
P
E
K
F
A
E
Q
L
I
R
Rat
Rattus norvegicus
XP_230789
677
77635
K605
V
S
Q
L
L
P
Q
K
F
A
E
Q
L
I
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q5ZJL9
614
70202
T536
V
S
R
L
L
P
G
T
F
S
E
Q
V
I
R
Frog
Xenopus laevis
Q6INN8
632
72730
Y559
A
E
Q
I
I
R
V
Y
C
K
K
T
D
E
K
Zebra Danio
Brachydanio rerio
Q502K2
622
71649
Y532
A
E
Q
L
I
R
V
Y
C
K
K
T
D
D
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q09374
587
66474
N515
S
E
D
Y
V
I
N
N
C
P
R
M
A
T
K
Sea Urchin
Strong. purpuratus
XP_784786
594
68895
V524
Q
M
L
P
K
K
F
V
D
H
Y
I
R
L
Y
Poplar Tree
Populus trichocarpa
XP_002312899
477
54770
K407
L
E
R
I
S
F
F
K
D
Y
E
S
E
E
K
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_568580
473
54655
D403
E
C
I
N
F
Y
K
D
Y
D
S
A
E
K
F
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
58.9
79.5
73.5
N.A.
73.3
65.8
N.A.
N.A.
60
61.8
60.8
N.A.
N.A.
N.A.
22.5
46.8
Protein Similarity:
100
60.2
82.4
83.6
N.A.
83.2
76.2
N.A.
N.A.
74.9
75.3
74.1
N.A.
N.A.
N.A.
40.8
64.2
P-Site Identity:
100
6.6
93.3
80
N.A.
13.3
13.3
N.A.
N.A.
6.6
80
86.6
N.A.
N.A.
N.A.
20
0
P-Site Similarity:
100
13.3
100
80
N.A.
33.3
33.3
N.A.
N.A.
33.3
86.6
86.6
N.A.
N.A.
N.A.
46.6
13.3
Percent
Protein Identity:
28.2
N.A.
N.A.
30.5
N.A.
N.A.
Protein Similarity:
45
N.A.
N.A.
47.2
N.A.
N.A.
P-Site Identity:
13.3
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
40
N.A.
N.A.
13.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
39
0
0
0
0
0
0
0
0
16
0
8
16
8
0
% A
% Cys:
0
8
0
0
0
0
0
0
47
0
0
0
0
0
0
% C
% Asp:
0
0
8
0
8
0
8
8
16
16
0
0
39
8
16
% D
% Glu:
8
54
0
0
0
0
8
0
0
0
31
0
16
16
0
% E
% Phe:
0
0
0
0
8
8
16
0
24
0
0
8
0
0
8
% F
% Gly:
0
0
8
0
0
0
8
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% H
% Ile:
0
0
8
24
39
8
0
0
0
0
0
8
0
24
0
% I
% Lys:
0
0
0
0
8
8
8
31
0
39
39
0
0
8
47
% K
% Leu:
8
0
8
54
24
0
0
0
0
0
0
0
16
8
0
% L
% Met:
0
8
0
0
0
0
0
0
0
0
0
16
0
0
0
% M
% Asn:
0
8
0
8
0
0
8
8
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
8
0
24
0
0
0
8
0
0
0
0
0
% P
% Gln:
8
0
54
0
0
0
8
0
0
0
0
24
0
0
0
% Q
% Arg:
8
0
16
0
0
39
0
0
0
0
8
0
8
24
24
% R
% Ser:
8
24
0
0
8
0
0
0
0
8
8
8
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
8
0
0
0
24
0
8
0
% T
% Val:
24
0
0
0
8
8
39
8
0
0
0
8
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% W
% Tyr:
0
0
0
8
0
8
0
39
8
8
16
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _